Edward J. Massaro, John M. Rogers"The Skeleton"
Humana Press | January 13, 2005 | ISBN: 1588292150 | Pages: 456 | PDF | 12.39 MB
A cutting-edge review of the biochemical, physiological, pharmacological, genetic, and molecular interactions involved in the development and homeostasis of the skeleton. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors' understanding of bone physiology-and how it is modified throughout all the stages of life-offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity situations (space flight), and hastening the healing of fractures, osteotomies, and antrodeses.With the World Health Organization's Decade of Bone and Joint Disease report and the 2004 U.S. Surgeon General's report on bone health and osteoporosis, we are reminded of the prevalence and cost of postmenopausal osteoporosis and fractures, cancer metastases to bone, and a host of endocrine and genetic disorders that have a primary impact on cartilage and bone. (Figure) The Skeleton will not guide the clinician in the management of skeletal disorders. Rather, Massaro and Rogers have assembled a series of review articles on selected topics in skeletal biology that will be most useful to researchers seeking an overview of particular topics or to cross-disciplinary practitioners with an interest in bone biology.