Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers by Gabriella Castoria; Antimo Migliaccio
December 8, 2011 | ISBN: 1461417635 | Pages: 270 | PDF | 5 MB
Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness.